![]() ![]() The aim was further confirm the efficacy and mechanism of the two treatment methods, to judge which treatment method is more suitable for clinical use, and to provide more reliable reference opinions for the future treatment of such diseases. Therefore, this study judged myocardial injury by detecting the miR-30a expression level before and after ACOP patients received hyperbaric oxygen therapy and ECMO respectively, and detected myocardial enzymes: creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH). ![]() Physiological autophagy has a protective effect in myocardial ischemia, and miR-30a can maintain autophagy reaction of myocardial cells after hypoxia ( 9), so miR-30a is bound to have an important connection with cardiac injury of ACOP. In recent years, due to the development of extracorporeal circulation technology, extracorporeal membrane oxygenation (ECMO) technology has been gradually applied to the treatment of ACOP, and Simonsen et al ( 8) reported that ECMO treatment can improve the survival rate of ACOP patients with cardiogenic shock, but its exact efficacy is currently less studied. However, due to the lack of efficacy basis, the application of hyperbaric oxygen to ACOP patients still lacks relevant evidence ( 7). At present, clinical treatment for ACOP includes hyperbaric oxygen therapy on the basis of symptomatic treatment, which can effectively reduce the mortality rate of patients ( 6). Among them, myocardial injuries such as angina pectoris and myocardial infarction ( 4) are common in ACOP patients and are related to the increase of long-term mortality rate ( 5). In ACOP, the main harm is to organs with high oxygen demand, including heart and brain, and the severity of the disease may be related to different concentrations of CO exposure and duration ( 3). Its pathogenesis is not completely clear and its physiological mechanism is mainly hypoxia stress. A considerable number of patients have long-term neurological and emotional sequelae after treatment ( 2). Its clinical manifestations range from headache, dizziness to coma and even death with a mortality rate of 1-3%. Acute carbon monoxide poisoning (ACOP) is a common acute disease in clinical practice. The concentration of CO exceeding 35 ppm will endanger human health ( 1). It is believed that miR-30a can provide a reference index for early diagnosis and prediction of disease progression and prognosis in cardiac injury of ACOP.Īs a colorless and tasteless gas, carbon monoxide (CO) is difficult to find when it overflows. The expression level of miR-30a in blood of ACOP patients increased significantly, which is positively correlated with myocardial injury, and it decreased after treatment. Both hyperbaric oxygen therapy and ECMO therapy have obvious efficacy on ACOP patients, but the latter is better than the former. The expression level of miR-30a in the RG was significantly higher than that in the control group (P<0.05). The concentrations of CK-MB and LDH in group A and group B were significantly higher than those in control group (P<0.01). Patients in groups A and B achieved obvious efficacy, but the effective rate and incidence rate of complications in the extracorporeal membrane oxygenation (ECMO) group were better than those in the hyperbaric oxygen group. Expression of miR-30a in the blood of experimental subjects was detected by time-fluorescence quantitative PCR, and the relationship between miR-30a expression and ACOP patients was analyzed. ![]() The concentrations of creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) of myocardial enzymes at different time points before and after treatment were detected. The effective rates and complications of the two groups after treatment were compared. Thirty-five patients in the RG who received hyperbaric oxygen therapy were considered as group A, and 35 patients who received extracorporeal membrane oxygenation therapy were considered as group B. Seventy patients with moderate and severe acute carbon monoxide poisoning (ACOP) admitted from January 2017 to December 2018 into The Affiliated Hospital of Qingdao University were regarded as a research group (RG), and another 30 healthy adults undergoing physical examination in the hospital during the same period were selected as a control group (CG). This study was designed to investigate cardiac injury after acute carbon monoxide poisoning and its clinical treatment scheme. ![]()
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